In order to solve the low-quality and degeneration problem of particles in the process of particle filtering, a multisensor information fusion algorithm based on intelligent particle filtering was proposed. The process of the proposed algorithm was divided into two steps. Firstly, the multisensor data was sent to the appropriate particle filtering calculation module, and the proposal distribution density was updated for the purpose of optimizing the particle distribution. Then, the integrated likelihood function model was structured by using the multisensor data in intelligent particle filtering module, meanwhile, the small-weight particles were modified into large-weight ones according to the designed genetic operators. The posterior distribution was more sufficiently approximated, thus large-weight particles were reserved in the process of resampling, which avoided the problem of exhausting particles, further maintained the diversity of the particles and improved the filtering precision. Finally, the optimal accurate estimated value was obtained. The proposed algorithm was applied to the GPS/SINS/LOG integrated navigation system according to the prototype testing data, and its effectiveness was verified by the simulation calculation. The simulation results show that, the proposed algorithm can get accurate informations of location, speed and heading, and effectively improve the filtering performance, which can improve the calculating precision of the integrated navigation system and meet the requirement of high precision navigation and positioning of the ship.